Assistant Project Scientist - Cancer Proteomics and Drug Discovery - Rape Lab - Department of Molecular and Cell Biology

The Department of Molecular and Cell Biology at the University of California, Berkeley seeks applications for an Assistant Project Scientist in the Rape Lab in the area of AML cancer proteomics and drug discovery.

This position is based on recent discoveries in the PI's lab that suggested that an understanding of protein degradation pathways in AML can form the basis for novel therapeutic approaches. This project will build on genetic discoveries that allow the lab to develop small molecules that modulate an important degradation step in AML cells. Experience in AML, genetic screens, and small molecule discovery is required.

The duties of the position include:

* Carrying out and analyzing whole genome CRISPR synthetic lethality screens

* Carrying out proteomics analysis

* Developing cell lines with endogenous tags and deletions using CRISPR

* Reconstituting ubiquitylation reactions

* Performing small molecule screens to disrupt ubiquitylation in cells.

* Correlating results or genetic and chemical biology screens with clinical data in AML

* Managing and analyzing data

* Pursuing publication of research in peer-reviewed journals;

* Pursuing additional funding opportunities consistent with existing and future research programs and goals

* Developing and troubleshooting new related research directions

* Training and mentoring lab members

This position provides full benefits.

Lab: https://ubiquitin.berkeley.edu/

Contract: https://ucnet.universityofcalifornia.edu/resources/employment-policies-contracts/bargaining-units/academic-researchers/contract/

PhD, MD, or equivalent international degree

*Publication record in peer-reviewed journals of research relevant to the job duties

*PhD or equivalent international degree in Molecular Genetics, Cell Biology, Developmental Biology, Biochemistry, or related field

* Experience publishing lead author primary research in peer-reviewed journals.

* Experience collaborating with other scientists

* Experience working with AML cancer genetics

* Experience with advanced proteomics and whole genome CRISPR screening approaches

* Track record of excellence in mentored research program

* Demonstrated ability to effectively communicate, participate in efficient and open collaboration, and enjoy engaging with a diverse group of researchers.

* Self-motivated, interactive, and meticulous approach to tasks and the ability to work both independently and as part of a team

* Innovative and able to synergize various ideas and approaches, while exercising sound judgment to evaluate and take acceptable risks.

• 3-5 required (contact information only)

UC Berkeley is committed to diversity, equity, inclusion, and belonging. The excellence of the institution requires an environment in which the diverse community of faculty, students, and staff are welcome and included. Successful candidates will demonstrate knowledge and skill related to ensuring equity and inclusion in the activities of their academic position (e.g., teaching, research, and service, as applicable).

The University of California, Berkeley is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.

Please refer to the University of California's Affirmative Action Policy and the University of California's Anti-Discrimination Policy.

In searches when letters of reference are required all letters will be treated as confidential per University of California policy and California state law. Please refer potential referees, including when letters are provided via a third party (i.e., dossier service or career center), to the UC Berkeley statement of confidentiality prior to submitting their letter.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct, are currently being investigated for misconduct, left a position during an investigation for alleged misconduct, or have filed an appeal with a previous employer.

• "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, discrimination, dishonesty, or unethical conduct, as defined by the employer.
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