Senior Scientist - Bioanalytical Method Development (LC-MS/MS)

Senior Scientist - Bioanalytical Method Development LC-MS/MS

The Senior Method Development Scientist will develop bioanalytical methods utilizing contemporary mass spectrometry techniques (LC-MS/MS & HRMS) and in collaboration with Inotiv's Bioanalytical Group within the Drug Metabolism & Pharmacokinetics Department. The range of method development activities will include but not be limited to traditional small molecules, antibodies, fusion proteins, ADCs, oligonucleotides, and peptide therapeutics, spanning early discovery staged activities through drug candidate selection. As part of the DMPK Department the senior method development scientist will support the broader Discovery and Translational Sciences Division, serving as a subject matter expert in scoping new bioanalytical proposals for clients, evaluating feasibility of LC-MS/MS method development, troubleshooting challenging methods across a wide variety of species and matrices, and partner with pharmacology and toxicology teams to execute in vitro, in vivo, and ex vivo investigations.

Join Inotiv in embracing research and science to impact the health and well-being of people all over the world.

Essential Duties and Responsibilities

• Develop highly sensitive LC-MS/MS and HRMS methods for large (oligonucleotides, proteins, antibodies, ADCs, biomarkers, etc) and small molecules in biological matrices.
• Utilize and interpret scientific theories, concepts, techniques in bioanalytical and mass spectrometry studies and accepts leadership role in developing novel scientific approaches
• Coordinate, facilitate, and implement intercompany method transfers and implementation of incoming transfers from clients.
• Communicate project timelines, status, and data to Principal Investigators, Project Management, and clients effectively addressing any issues that may arise.
• Ability to coordinate and execute on multiple projects simultaneously and responsive to unscheduled deadlines and client needs.
• Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21CFR, Part 58) as these relate to study-specific services provided, this job description, and general facility operations.
• Training and mentoring junior scientists within and across departments
• Collaborate with leadership on long-range planning and strategy for departmental growth
• Performs other duties as assigned.

Skills and Abilities

• Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC-MS/MS, HRMS), instrument operation, maintenance, and data processing.
• Proven track record of method development for large and small molecules
• Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory.
• Working knowledge of laboratory software, system software, and Microsoft applications
• Independence in the laboratory and data work-up phases of research.
• A working knowledge and awareness of general laboratory procedures.
• Good written and oral communication skills.
• Ability to adhere to all safety regulations and procedures.

Education and Experience

• PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training
• M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience
• Candidates possessing working knowledge of in vitro metabolism/biotransformation, Pharmacokinetic modeling, analysis, interpretation and simulation desirable

Physical Activity and Working Conditions

• Work is normally performed in a typical interior office work or laboratory environment
• Work environment involves exposure to potentially dangerous materials and situations that require following extensive safety precautions and may include use of protective equipment
• The noise level is usually moderate
• This position will frequently be involved with radiant/electrical energy, solvents, grease, oil, irritants, acids, bases, and other hazardous chemicals, electro-mechanical hazards, flammable materials and bio-hazards. Due to exposure to hazardous biological material (which may include HIV positive specimens), immunization to Hepatitis B and/or other diseases may be a requirement.

Salary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K participation with company match, and more!

Inotiv is an Equal Opportunity Employer. It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, gender, gender identity, sexual orientation, physical or mental disability, national origin, veteran status, or any other basis prohibited by law. This policy governs all aspects of employment, including selection, job assignment, compensation, discipline, termination and access to benefits and training.

*This position could be offered at different levels for candidates who qualify with a combination of advanced levels of education and/or years of experience. The salary range will adjust along with the level of the role to match the person's relevant experience and/or education level.

Inotiv is a growing contemporary drug discovery and development company where we "Play to Win" in an industry rich with opportunity. Together, we face challenges and together we win in the delivery of world-class drug discovery and development solutions that impact the health and well-being of people all over the world. There's an opportunity for everyone at all phases of a career, each individual's unique skill set has an impact on the work we conduct. If you have the talent and desire to impact the quality of people's lives, we have the career opportunities to make it happen. Join us in embracing research and science to impact the health and well-being of people all over the world.

Salary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K, and more!

Inotiv is an Equal Opportunity Employer. It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, sex, gender, gender identity, gender expression, sexual orientation, genetic information, disability, national origin, veteran status, or any other basis prohibited by law. This policy governs all aspects of employment, including selection, job assignment, compensation, discipline, termination and access to benefits and training.