Research Postdoctoral Fellow - Warren Lab

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A Brief Overview
Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

The Warren laboratory at the Children's Hospital of Philadelphia is seeking a highly motivated, collaborative, and creative post-doc to join our growing team. We study normal and malignant hematopoiesis. Our work is informed by the study of germline disorders that cause global failure of hematopoiesis (bone marrow failure syndromes) or those that specifically impact neutrophil formation (severe congenital neutropenia). We have a particular interest in genes that impact mitochondrial function, and how this translates into impaired stem and progenitor cell function. Our long-term goal is to use the knowledge gained from studying the biology of hematopoiesis and granulopoiesis to develop new therapies and surveillance strategies. This could impact patients with rare inherited bone marrow failure disorders, but also patients undergoing treatments such as hematopoietic stem cell transplantation, chemotherapy, or gene therapy.

Current projects in the lab investigate:

• Understanding the role of a mitochondrial protein folding chaperone (CLPB) in normal granulopoiesis
• Investigating the hematopoietic stem and progenitor cell phenotype of CLPB-deficient mice
• Studying the role of RUNX1 somatic mutations in pre-leukemic evolution within congenital neutropenia syndromes
• CRISPR/Cas9 screen and high-throughput drug screen to identify essential determinants of granulopoiesis to develop a cell therapy

Joining the Warren laboratory would provide the following:

• Access to state-of-the-art facilities at the CHOP, Penn, and Wistar institutes
• Collaborative research environment working with world leaders in basic and translational hematopoiesis / leukemia biology
• Opportunities to participate in multiple work-in-progress style meetings with field leaders, and to attend seminars across the CHOP and Penn campuses
• Strong, available mentorship with a focus on the post-doctoral scholar's long-term career development

Strong candidates will possess the following traits and skills:

• Good communication, strong interest in collaboration
• Strong organizational skills, attention to detail, experience with learners
• Laboratory skills including:
  • Animal handling, colony management
  • Multi-color flow cytometry (prefer experience with at least 7-8 color flow)
  • Fluorescence assisted cell sorting (FACS)
  • Sterile tissue culture of both adherent and suspension cells
  • Production of lenti- or retro-virus

Interested candidates should prepare the following:

• A cover letter describing research experiences and career goals
• Curriculum vitae
• Contact information for three references

What you will do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

Education Qualifications

• Doctorate Required

Skills and Abilities

• Ability to wear a respirator device

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SALARY RANGE:

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

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