New

Research Scientist I or II, Oligonucleotide Chemistry

Novartis Group Companies
parental leave
United States, Massachusetts, Cambridge
Aug 13, 2026
Job Description Summary Job Title: Research Scientist I or II, Oligonucleotide Chemistry #LI-Onsite Location: Cambridge, USA Relocation Support: This role is based in Cambridge, USA. Novartis is unable to offer relocation support: please only apply if accessible. Imagine helping shape the future of RNA-based medicines through hands-on scientific innovation. At Novartis, we're pushing the boundaries of xRNA therapeutics to address some of the world's most challenging diseases, and we're looking for a talented scientist to join us on that journey. As a Research Scientist in Oligonucleotide Chemistry, you'll play a key role in synthesizing, optimizing, and characterizing therapeutic oligonucleotides while collaborating with a diverse team of experts across discovery and development. This is an exciting opportunity to apply your scientific expertise, grow your technical skills, and contribute directly to groundbreaking therapies that have the potential to transform patients' lives. Job Description Key Responsibilities Execute solid-phase synthesis of research-scale oligonucleotides using advanced automated DNA and RNA synthesizers. Purify, desalt, and characterize oligonucleotides using chromatographic and mass spectrometry techniques. Develop and optimize synthesis, purification, and analytical methods to improve performance and reproducibility. Operate, maintain, and troubleshoot laboratory instrumentation supporting oligonucleotide production and analysis. Prepare and maintain standard operating procedures to support high-quality and consistent laboratory practices. Organize, analyze, and document experimental results using electronic laboratory notebook systems. Contribute effectively within a collaborative, fast-paced research environment focused on therapeutic innovation. Essential Requirements Bachelor of Science or Master of Science in Chemistry or a related scientific discipline. One to three years of laboratory experience in academic or industrial research environments. Hands-on experience with automated solid-phase synthesizers and therapeutic oligonucleotide synthesis workflows. Proficiency in oligonucleotide purification, characterization, and analysis using chromatography and mass spectrometry techniques. Understanding of RNA therapeutics and their application in biological systems. Strong collaboration, adaptability, and self-motivation in a fast-paced scientific environment. Desirable Requirements Experience supporting oligonucleotide process development, optimization, or technology innovation initiatives. Excellent scientific communication skills with the ability to present findings to multidisciplinary teams. Rewards At Novartis,we'recommitted to reimagining medicine together - and rewarding the people who make it happen. The rewards of being part of our team go far beyond base pay and incentives.We also offer a variety of competitive benefits inkindto help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeingresourcesand global recognition programs. In addition, we provide flexible and hybrid working options, where possible, anda minimum of14 weekspaid parental leave. Expected Annual Base Salary Range for role: US:66,800.00 - 124,000.00 USD Annual The salary offered isdeterminedbased on gender-neutralobjectives, such as relevant skills,competenciesand experiencein accordance withthe Novartis pay setting policy and upon joining Novartis will be reviewed periodically. In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Further details will be provided during the application process. Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse,equitableand inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics. Readourbrochureto learn more about our global total rewards offering:https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the applicationprocess. Commitment to Diversity and Inclusion / EEO paragraph: Novartis is committed to building an outstanding, inclusive work environment and diverseteams'representativeof the patients and communities we serve. Why Novartis:Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating,supportingand inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together?https://www.novartis.com/about/strategy/people-and-culture EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $66,800.00 - $124,000.00 Skills Desired Algorithms, Analytical Chemistry, Automation, Chemical Analysis, Chemical Biology, Chemical Laboratory, Chemical Synthesis, Chemistry, Collaboration, Creativity, Data Analysis, Drug Development, Innovation, Medicinal Chemistry, Organic Chemistry, Pharmaceutical Industry, Physics, Team Player