Research Scientist II or Senior Scientist, Oncology Drug Discovery

Novartis Group Companies
United States, Massachusetts, Cambridge
Jan 07, 2025
Job Description Summary The Biotherapeutics group within Oncology Drug Discovery at Novartis Biomedical Research is seeking a highly motivated and collaborative Research Scientist II to advance drug-conjugate discovery programs for the treatment of cancer patients. In this lab-based role, the successful candidate will apply cell and molecular biology techniques to deliver impactful data for target validation and drug optimization efforts. This role requires a strong understanding of and experience with in vitro cell-based assays for drug discovery. This individual will interact collaboratively with colleagues across Biomedical Research and will be a member of multidisciplinary project teams. This a great opportunity to join a group dedicated to the discovery of biotherapeutics and to support advancement of drug discovery projects into the Novartis portfolio. Job Description Responsibilities include, but are not limited to: Generates hypotheses to test, troubleshoots issues and designs and executes the next set of experiments with some input from senior lab members/manager. Works independently and as a part of a team to design, execute, and analyze in vitro experiments to profile small molecules and biologics and elucidate mechanisms of action Executes cell and molecular biology assays (e.g. cell titer glo, flow cytometry, JESS, western blot, MSD, HTRF) Cultures cells using sterile technique including genetic engineering and validation of cell lines Uses laboratory automation equipment (liquid handlers, plate readers, dispensers) to perform screens Maintains an organized and detailed record of all experiments Works collaboratively across teams and trains other members of team in areas of technical expertise as needed. Clearly communicates findings and presents research to multidisciplinary project teams Supports lab operations including management of materials, maintenance of instruments, and general lab duties Minimum requirements: BS/MS Degree in biology or related field Minimum 2+ years of bench work experience in a cancer biology lab Demonstrated ability to analyze, interpret and present data in a clear manner and use data to generate new hypotheses Hands-on experience with cellular assay development & execution Level will commensurate with experience Highly self-motivated, collaborative team worker with exceptional organizational skills and curiosity to expand and diversify skillsets Desirable experience: Understanding of drug discovery optimization processes Experience with discovery of antibody-drug-conjugates Previous industry experience preferred EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers who are focused on building and advancing a culture of inclusion that values and celebrates individual differences, uniqueness, backgrounds and perspectives. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to fostering a diverse and inclusive workplace that reflects the world around us and connects us to the patients, customers and communities we serve. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $77,000.00 - $143,000.00 Skills Desired Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical Trials, Collaboration, Communication Skills, Curiosity, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Diversity & Inclusion, Drug Discovery, Ethics, Gene Therapy, Immunology, Laboratory, Lifesciences, Machine Learning (Ml), Mammalian Cell Culture, Medical Research, Molecular Biology {+ 11 more}